Aeroallergen Cross-reactivity Tables for Formulating IT

Component Allergen Cross-reactivity Table for Formulating IT

Note:

Despite 75-80% homology, sensitization to tropomyosins (e.g. dust mite Der p 10) may be a good marker of clinical sensitivity to crustaceans but not to mites
- In patients with true crustacean food allergy and positive SPT to mites, evaluating for specific dust mite markers (Der p 1/2, Der f 1/2) may be required to confirm true dust mite sensitivity
Due to cat/dog/horse serum albumin cross-reactivity (Fel d 3, Can f 3, Equ c 3), evaluation for specific markers for cat, dog, and horse (Fel d 1/4, Can f2/5, Equ c 1) may be required to confirm true cat, dog, or horse sensitivity when there is multiple SPT positivity to these animals
False negative SPT to dog may be due to patient sensitization to Can f 5 (prostate derived allergen produced by male dogs that is poorly represented in SPT extracts made from dander)
- Can f 5 sensitivity can be evaluated by component testing and this may explain patient reports of sensitivity to specific dogs
Clinical relevance of profilin as an aeroallergen is unknown, but there is evidence that it can induce symptoms in nasal/bronchial challenge tests